MKE could refer to:
- Milwaukee, Wisconsin
- General Mitchell International Airport in Milwaukee, Wisconsin; IATA airport code MKE.
- Mechanical and Chemical Industry Corporation (Turkey), in Turkish, Makina ve Kimya Endustrisi Kurumu
- Milwaukee Intermodal Station; Amtrak station code MKE.
- MKE (tabloid), a weekly publication in Milwaukee which ended in 2008.
- MKE Ankaragücü, a Turkish football club in Ankara
- MKE Kırıkkalespor, a Turkish football club in Kirikkale
- MSDW Structured Asset Corporation, New York Stock Exchange symbol MKE.
- Matsushita Kotobuki Electronics, referring to the obsolete Panasonic CD interface also known as SLCD.
- Ministry of Knowledge Economy (MKE), now the Ministry of Trade, Industry and Energy (MOTIE)
MKE was a weekly publication in Milwaukee, Wisconsin published by Journal Communications. Launched on October 28, 2004 as a zero-news-content cross between an alternative weekly and a weekly entertainment magazine aimed at readers under 35, it (along with the online version, MKEOnline.com) also served as a secondary advertising vehicle for the Milwaukee Journal Sentinel, its parent publication. At the time of its launch, it was seen as competing for the same readership as the Shepherd Express. A representative for the Association of Alternative Newsweeklies (of which the Shepherd Express was a member) was quoted as saying that three dozen daily newspapers had rolled out weekly free publications during the past year alone. He characterized them as "usually pretty fluffy" and presented with "faux hipness," and said of MKE: "Milwaukee's a little different because they've actually come out and said there's no news at all," and predicted most of the new free newspapers would fail in the long run because they lacked the "idiosyncrasies and oddball charm" of true alternative weeklies.
Described by local reporter and media critic Michael Horne as "pretty darn lame", it never found a profitable marketing niche; ad revenues peaked in 2006 and never recovered. MKE ceased publication after the July 11, 2008, issue.