Wikipedia
Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the MARCKS gene. It plays important roles in cell shape, cell motility, secretion, transmembrane transport, and regulation of the cell cycle. Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin.
They are acidic proteins with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca/ calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2.
Marcks is a surname. Notable people with the surname include:
- Erich Marcks (1891–1944), German general
- Gerhard Marcks (1889–1981), German sculptor
- Greg Marcks (born 1976), American director, writer and actor
- Megan Marcks (born 1972), Australian rower
- Werner Marcks (1896–1967), German general