Lezo may refer to:
- Blas de Lezo (1689-1741), Spanish admiral
- Lezo, Aklan, municipality in the province of Aklan, Philippines
- Lezo, Spain, town and municipality in the province of Gipuzkoa, Basque Country, Spain
LEZO ( укр. ЛЕЗО) – Ukrainian hip-hop band founded in 2005 in Novovolynsk, Ukraine composed of Delta, Girya, Storog and Roks. In 2008 published their album "Gostroslovy" ( укр. Гострослови). Many critics consider it one of the best in Ukrainian hip-hop industry.