KXEN may refer to:
- KXEN (AM), a radio station (1010 AM) licensed to St. Louis, Missouri, United States
- KXEN Inc., a California software company
KXEN (1010 AM) is a radio station licensed to St. Louis, Missouri, USA. The station is owned by Bdj Radio Enterprises, LLC.
KXEN's transmitter is located near the Interstate 255/ Illinois Route 255/ Interstate 270 intersection in Pontoon Beach.