HWE may refer to:
- Hwe (Cyrillic), a letter of the Cyrillic script
- Hwe language, spoken in Ghana, Togo, and Benin
- Hardy–Weinberg equilibrium
- Home War Establishment of the Royal Canadian Air Force
- Horner–Wadsworth–Emmons reaction
- Hot water extraction
- Sunwoo Hwe, South Korean writer
Hwe (Ꚕ ꚕ; italics: Ꚕ ꚕ) is a letter of the Cyrillic script.
Hwe is used in the old Abkhaz alphabet, where it represents the voiceless pharyngeal fricative . It is a Cyrillic letter corresponding to Ҳә.