What is "herboxidiene"

Herboxidiene is a polyketide molecule soluble in polar solvents such as water, ethanol, n-butanol and acetone but insoluble in non-polar molecule such as hexane. It was first isolated from the fermentation broth of Streptomyces chromofuscus by researchers in Monsanto Company in 1992. Herboxidiene shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome. Many antitumor derivatives have also been developed from herboxidiene through chemical modification.