EAE can refer to:
- Encyclopædia Æthiopica, a reference work on Ethiopian and Eritrean studies
- Evangelistic Association Of The East, a diocese of Jacobite Syrian Church.
- Experimental autoimmune encephalomyelitis
- EAE Editorial Académica Española, an imprint of VDM Publishing
- European Air Express
- Eusko Abertzale Ekintza, a basque political party
- Edgar & Ellen, characters in a book and animation series