What is "dihydroxyphenylglycine"

(S)-3,5-Dihydroxyphenylglycine or DHPG is a potent agonist of group I metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5.

DHPG was the first agonist shown to be selective for group I mGluRs. Agonist activity is found in only the (S)- isomer, and (S)-DHPG may be a partial agonist of group I mGluRs.

(S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease.

3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia.