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The Collaborative International Dictionary
Defatigate

Defatigate \De*fat"i*gate\, v. t. [L. defatigatus, p. p. of defatigare; de- + fatigare to weary. See Fatigue.] To weary or tire out; to fatigue. [R.]
--Sir T. Herbert.

Wiktionary
defatigate
  1. (context obsolete rare English) weary; fatigued v

  2. (context rare English) To tire or make weary