Aplu may mean:
- Aplu (deity), a Hurrian deity of the plague.
- An acronym for the Association of Public and Land-Grant Universities (US).
Aplu was a Hurrian deity of the plague — bringing it, or, if propitiated, protecting from it — and resembles Apollo Smintheus, "mouse-Apollo" Aplu, it is suggested, comes from the AkkadianAplu Enlil, meaning "the son of Enlil", a title that was given to the god Nergal, who was linked to Shamash, Babylonian god of the sun.
Aplu may be related with Apaliunas who is considered to be the Hittite reflex of *Apeljōn, an early form of the name Apollo.