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Apaxco is a municipality located in Zumpango Region, the northeastern part of the State of Mexico in Mexico, although both are commonly called Apasco. The municipal territory is located at a southern pass leading out of the Mezquital Valley and about northeast of the state capital of Toluca. This name comes from Nahuatl and means "place of the water fall".

The municipality was founded on October 16, 1870. It covers an area of . Apaxco de Ocampo is a municipal seat, and also is a border city with Vito and El Refugio, between the State of Mexico and the State of Hidalgo; inside of Cuenca cementera (Cement basin), an important area for the building industry but with ecological problems.