What is "aggresome"

n. (context physiology English) A proteinaceous inclusion body that forms when cellular degradation machinery is impaired or overwhelmed

In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein-degradation system of the cell is overwhelmed. Aggresome formation is a highly regulated process which possibly serves to organize misfolded proteins into a single location.