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Answer for the clue "Shoe designation ", 3 letters:
eee

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Wikipedia Word definitions in Wikipedia
EEE , or 2,4,5- triethoxy amphetamine , is a lesser-known psychedelic drug . It is the triethoxy analog of TMA-2 . EEE was first synthesized by Alexander Shulgin . In his book PiHKAL (Phenethylamines i Have Known And Loved) , both the dosage and duration ...